An ultrafast insulin formulation enabled by high-throughput screening of engineered polymeric excipients

Nootropic Medicinal Plants; Evaluating Potent Formulation By Novelestic High throughput Pharmacological Screening (HTPS) Method

The principle of this method was to screen the pharmacological activity of six prepared polyphyto formulations by using high throughput screening method for their nootropic action. The study was performed in three stages using one, two and three animals, respectively in a group. Test formulations were given p.o daily at the dose of 50 and 100 mg/kg body weight. The test formulations were compar...

Polymeric plant-derived excipients in drug delivery.

Drug dosage forms contain many components in addition to the active pharmaceutical ingredient(s) to assist in the manufacturing process as well as to optimise drug delivery. Due to advances in drug delivery technology, excipients are currently included in novel dosage forms to fulfil specific functions and in some cases they directly or indirectly influence the extent and/or rate of drug releas...

Electrochemistry-enabled fabrication of orthogonal nanotopography and surface chemistry gradients for high-throughput screening.

Gradient surfaces are emerging tools for investigating mammalian cell-surface interactions in high throughput. We demonstrate the electrochemical fabrication of an orthogonal gradient platform combining a porous silicon (pSi) pore size gradient with an orthogonal gradient of peptide ligand density. pSi gradients were fabricated via the anodic etching of a silicon wafer with pore sizes ranging f...

Stimuli-Responsive Hydrogel Microdomes Integrated with Genetically Engineered Proteins for High-Throughput Screening of Pharmaceuticals

Validation and Screening in a High Throughput Mechanical Injury Model of Engineered Cartilage

Introduction Joint injuries increase the likelihood of developing post-traumatic osteoarthritis (PTOA) due to the initiation of catabolic processes that lead to progressive degeneration of the joint cartilage. Several in vitro models have been developed (using chondral explants) to investigate the pathologic mechanisms of PTOA and to evaluate the efficacy of putative small molecule therapeutics...